Make your reservations at www.amtrak.com. This train is one of Amtrak's Northeast Regional routes.
When making reservations, go to Amtrak's Home page, type in your Station of Departure, Station of Arrival, and Date of Travel in the box to the left. If you leave the Time blank, then click "GO", the next screen will show all the routes and times serving your stations. You can choose among the options. Notice that the Northeast Regional Lynchburg train is considerably less expensive than the daily Crescent, while serving the same stations. Promotional fares are available through March 31, 2010.